Ray McDonald is the only major injury concern for the 49ers. He suffered a hamstring injury against Cleveland and missed the game vs. Washington.
The Giants will be without Ahmad Bradshaw and possibly Hakeem Nicks, who is a game time decision.
Alex Smith has been very solid this season partly because he has had better pass protection than in previous years and that will be needed if they are to have success against the Giants. Jason Pierre-Paul, Osi Umenyiora, and Justin Tuck are capable of disrupting the passing game which puts the spotlight on Joe Staley and Anthony Davis.
Get to Eli
Eli Manning is playing as well as he has at any point in his career and the 49ers have to get pressure on him or it could be a long afternoon. Justin Smith, Aldon Smith, and Ahmad Brooks need to make him uncomfortable in the pocket and force him to make some turnovers.